{"id":341,"date":"2017-08-04T17:49:58","date_gmt":"2017-08-04T15:49:58","guid":{"rendered":"https:\/\/www.pharmarte.com\/?p=341"},"modified":"2017-08-04T17:49:58","modified_gmt":"2017-08-04T15:49:58","slug":"endocrine-and-clinical-effects-of-myo-inositol-administration-in-polycystic-ovary-syndrome-a-randomized-study","status":"publish","type":"post","link":"https:\/\/www.pharmarte.com\/en\/endocrine-and-clinical-effects-of-myo-inositol-administration-in-polycystic-ovary-syndrome-a-randomized-study\/","title":{"rendered":"Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study."},"content":{"rendered":"<div id=\"container\" class=\"hfeed\">\n<div id=\"wrapper\" class=\"clearfix\">\n<div id=\"content\" class=\"grid col-620\">\n<div id=\"post-707\" class=\"post-707 post type-post status-publish format-standard hentry category-inotir\">\n<div class=\"post-meta\"><a title=\"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23336594#\">Gynecol Endocrinol.<\/a>\u00a02013 Apr;29(4):375-9.<\/div>\n<div class=\"post-entry\">\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Artini%20PG%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Artini\u00a0PG<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Di%20Berardino%20OM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Di Berardino OM<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Papini%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Papini F<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Genazzani%20AD%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Genazzani AD<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Simi%20G%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Simi G<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Ruggiero%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Ruggiero M<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Cela%20V%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23336594\">Cela V<\/a>.<\/p>\n<h3>Abstract<\/h3>\n<div>\n<div>\n<h5>OBJECTIVE:<\/h5>\n<p>To evaluate the effects the administration of\u00a0myo-inositol\u00a0(MYO) on hormonal parameters in a group of polycystic ovary syndrome (PCOS) patients.<\/p>\n<h5>DESIGN:<\/h5>\n<p>Controlled clinical study. Setting: PCOS patients in a clinical research environment. Patients: 50 overweight PCOS patients were enrolled after informed consent. Interventions: All patients underwent hormonal evaluations and an oral glucose tolerance test (OGTT) before and after 12 weeks of therapy (Group A (n\u00bc10):\u00a0MYO\u00a02 g plus folic acid 200 mg every day; Group B (n\u00bc10): folic acid 200 mg every day). Ultrasound examinations and Ferriman-Gallwey score were also performed. Main outcome measures: Plasma LH, FSH, PRL, E2, 17OHP, A, T, glucose, insulin, C peptide concentrations, BMI, HOMA index and glucose-to-insulin ratio.<\/p>\n<h5>RESULTS:<\/h5>\n<p>After 12 weeks of\u00a0MYO\u00a0administration plasma LH, PRL, T, insulin levels and LH\/FSH resulted significantly reduced. Insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment. Menstrual cyclicity was restored in all amenorrheic and oligomenorrheic subjects. No changes occurred in the patients treated with folic acid. Conclusions:\u00a0MYO\u00a0administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Gynecol Endocrinol.\u00a02013 Apr;29(4):375-9. Artini\u00a0PG,\u00a0Di Berardino OM,\u00a0Papini F,\u00a0Genazzani AD,\u00a0Simi G,\u00a0Ruggiero M,\u00a0Cela V. Abstract OBJECTIVE: To evaluate the effects the administration of\u00a0myo-inositol\u00a0(MYO) on hormonal parameters in a group<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[],"class_list":["post-341","post","type-post","status-publish","format-standard","hentry","category-bibliografia-inotir"],"_links":{"self":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/comments?post=341"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/341\/revisions"}],"predecessor-version":[{"id":342,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/341\/revisions\/342"}],"wp:attachment":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/media?parent=341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/categories?post=341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/tags?post=341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}