15-03-2013 \u2013 American Society for Clinical Nutrition<\/div>\n

Sjurdur F Olsen, Marie Louise \u00d8sterdal, Jannie Dalby Salvig, Lotte Maxild Mortensen, Dorte Rytter, Niels J Secher, and Tine Brink Henriksen<\/p>\n

Abstract<\/strong><\/p>\n

Background:<\/strong> Evidence suggests that asthma is rooted in the intrauterine environment and that intake of marine n\u22123 polyunsaturated fatty acids (n\u22123 PUFAs) in pregnancy may have immunomodulatory effects on the child.<\/p>\n

Objective:<\/strong> Our aim was to examine whether increasing maternal intake of n\u22123 PUFAs in pregnancy may affect offspring risk of asthma.<\/p>\n

Design:<\/strong> In 1990, a population-based sample of 533 women with normal pregnancies were randomly assigned 2:1:1 to receive four 1-g gelatin capsules\/d with fish oil providing 2.7 g n\u22123 PUFAs (n = 266); four 1-g, similar-looking capsules\/d with olive oil (n = 136); or no oil capsules (n = 131). Women were recruited and randomly assigned around gestation week 30 and asked to take capsules until delivery. Among 531 live-born children, 528 were identified in registries and 523 were still alive by August 2006. Diagnoses from the International Coding of Diseases version 10 were extracted from a mandatory registry that recorded diagnoses reported from hospital contacts.<\/p>\n

Results:<\/strong> During the 16 y that passed since childbirth, 19 children from the fish oil and olive oil groups had received an asthma-related diagnosis; 10 had received the diagnosis allergic asthma. The hazard rate of asthma was reduced by 63% (95% CI: 8%, 85%; P = 0.03), whereas the hazard rate of allergic asthma was reduced by 87% (95% CI: 40%, 97%; P = 0.01) in the fish oil compared with the olive oil group.<\/p>\n

Conclusion:<\/strong> Under the assumption that intake of olive oil in the dose provided here was inert, our results support that increasing n\u22123 PUFAs in late pregnancy may carry an important prophylactic potential in relation to offspring asthma.
\n\u2022 Received March 17, 2008.
\n\u2022 Accepted April 8, 2008.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

15-03-2013 \u2013 American Society for Clinical Nutrition Sjurdur F Olsen, Marie Louise \u00d8sterdal, Jannie Dalby Salvig, Lotte Maxild Mortensen, Dorte Rytter, Niels J Secher, and Tine [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40],"tags":[],"class_list":["post-357","post","type-post","status-publish","format-standard","hentry","category-bibliografia-metra"],"_links":{"self":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/comments?post=357"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/357\/revisions"}],"predecessor-version":[{"id":358,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/357\/revisions\/358"}],"wp:attachment":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/media?parent=357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/categories?post=357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/tags?post=357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}