{"id":359,"date":"2017-08-04T18:02:38","date_gmt":"2017-08-04T16:02:38","guid":{"rendered":"https:\/\/www.pharmarte.com\/?p=359"},"modified":"2017-08-04T18:02:38","modified_gmt":"2017-08-04T16:02:38","slug":"randomised-clinical-trials-of-fish-oil-supplementation-in-high-risk-pregnancies-fish-oil-trials-in-pregnancy","status":"publish","type":"post","link":"https:\/\/www.pharmarte.com\/en\/randomised-clinical-trials-of-fish-oil-supplementation-in-high-risk-pregnancies-fish-oil-trials-in-pregnancy\/","title":{"rendered":"Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy"},"content":{"rendered":"<div id=\"container\" class=\"hfeed\">\n<div id=\"wrapper\" class=\"clearfix\">\n<div id=\"content\" class=\"grid col-620\">\n<div id=\"post-159\" class=\"post-159 post type-post status-publish format-standard hentry category-metra-dha-1g\">\n<div class=\"post-meta\">15-03-2013 \u2013 BJOG. 2000 Mar;107(3):382-95.<\/div>\n<div class=\"post-entry\">\n<p>Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>OBJECTIVE:<\/strong><\/p>\n<p>To test the postulated preventive effects of dietary n-3 fatty acids on pre-term delivery, intrauterine growth retardation, and pregnancy induced hypertension.<\/p>\n<p><strong>DESIGN:<\/strong><\/p>\n<p>In six multicentre trials, women with high risk pregnancies were randomly assigned to receive fish oil (Pikasol) or olive oil in identically-looking capsules from around 20 weeks (prophylactic trials) or 33 weeks (therapeutic trials) until delivery.<\/p>\n<p><strong>SETTING:<\/strong><\/p>\n<p>Nineteen hospitals in Europe.<\/p>\n<p><strong>SAMPLES: <\/strong><\/p>\n<p>Four prophylactic trials enrolled 232, 280, and 386 women who had experienced previous pre-term delivery, intrauterine growth retardation, or pregnancy induced hypertension respectively, and 579 with twin pregnancies. Two therapeutic trials enrolled 79 women with threatening pre-eclampsia and 63 with suspected intrauterine growth retardation.<\/p>\n<p><strong>INTERVENTIONS:<\/strong><\/p>\n<p>The fish oil provided 2.7 g and 6.1 g n-3 fatty acids\/day in the prophylactic and therapeutic trials, respectively.<\/p>\n<p><strong>MAIN OUTCOME MEASURES:<\/strong><\/p>\n<p>Preterm delivery, intrauterine growth retardation, pregnancy induced hypertension.<\/p>\n<p><strong>RESULTS: <\/strong><\/p>\n<p>Fish oil reduced recurrence risk of pre-term delivery from 33% to 21% (odds ratio 0.54 (95% CI 0.30 to 0.98)) but did not affect recurrence risks for the other outcomes (OR 1.26; 0.74 to 2.12 and 0.98; 0.63 to 1.53, respectively). In twin pregnancies, the risks for all three outcomes were similar in the two intervention arms (95% CI for the three odds ratios were 0.73 to 1.40, 0.90 to 1.52, and 0.83 to 2.32, respectively). The therapeutic trials detected no significant effects on pre-defined outcomes. In the combined trials, fish oil delayed spontaneous delivery (proportional hazards ratio 1.22; 1.07 to 1.39, P = 0.002).<\/p>\n<p><strong>CONCLUSIONS:<\/strong><\/p>\n<p>Fish oil supplementation reduced the recurrence risk of pre-term delivery, but had no effect on pre-term delivery in twin pregnancies. Fish oil had no effect on intrauterine growth retardation and pregnancy induced hypertension, affecting neither recurrence risk nor risk in twin pregnancies.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>15-03-2013 \u2013 BJOG. 2000 Mar;107(3):382-95. Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C. Abstract OBJECTIVE: To test the postulated preventive effects of<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40],"tags":[],"class_list":["post-359","post","type-post","status-publish","format-standard","hentry","category-bibliografia-metra"],"_links":{"self":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/comments?post=359"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/359\/revisions"}],"predecessor-version":[{"id":360,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/359\/revisions\/360"}],"wp:attachment":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/media?parent=359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/categories?post=359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/tags?post=359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}