{"id":384,"date":"2017-08-04T18:16:59","date_gmt":"2017-08-04T16:16:59","guid":{"rendered":"https:\/\/www.pharmarte.com\/?p=384"},"modified":"2017-08-04T18:16:59","modified_gmt":"2017-08-04T16:16:59","slug":"folate-folic-acid-and-5-methyltetrahydrofolate-are-not-the-same-thing","status":"publish","type":"post","link":"https:\/\/www.pharmarte.com\/en\/folate-folic-acid-and-5-methyltetrahydrofolate-are-not-the-same-thing\/","title":{"rendered":"Folate, folic acid and 5-methyltetrahydrofolate are not the same thing."},"content":{"rendered":"<div id=\"container\" class=\"hfeed\">\n<div id=\"wrapper\" class=\"clearfix\">\n<div id=\"content\" class=\"grid col-620\">\n<div id=\"post-1411\" class=\"post-1411 post type-post status-publish format-standard hentry category-mthfr-prevent-plus\">\n<div class=\"post-entry\">\n<p>Scaglione\u00a0F<sup>1<\/sup>,\u00a0Panzavolta\u00a0G.<\/p>\n<h3>Author information<\/h3>\n<h3>Abstract<\/h3>\n<ol>\n<li>Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism. Mammals cannot synthesize folate and depend on supplementation to maintain normal levels. Low folate status may be caused by low dietary intake, poor absorption of ingested folate and alteration of folate metabolism due to genetic defects or drug interactions. 2. Folate deficiency has been linked with an increased risk of neural tube defects, cardiovascular disease, cancer and cognitive dysfunction. Most countries have established recommended intakes of folate through folic acid supplements or fortified foods. External supplementation of folate may occur as folic acid, folinic acid or 5-methyltetrahydrofolate (5-MTHF). 3. Naturally occurring 5-MTHF has important advantages over synthetic folic acid \u2013 it is well absorbed even when gastrointestinal pH is altered and its bioavailability is not affected by metabolic defects. Using 5-MTHF instead of folic acid reduces the potential for masking haematological symptoms of vitamin B12 deficiency, reduces interactions with drugs that inhibit dihydrofolate reductase and overcomes metabolic defects caused by methylenetetrahydrofolate reductase polymorphism. Use of 5-MTHF also prevents the potential negative effects of unconverted folic acid in the peripheral circulation. 4. We review the evidence for the use of 5-MTHF in preventing folate deficiency.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Scaglione\u00a0F1,\u00a0Panzavolta\u00a0G. Author information Abstract Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism. Mammals cannot synthesize folate and depend on supplementation to maintain normal<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-384","post","type-post","status-publish","format-standard","hentry","category-bibliografia-mthfr-prevent-plus"],"_links":{"self":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/comments?post=384"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/384\/revisions"}],"predecessor-version":[{"id":385,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/posts\/384\/revisions\/385"}],"wp:attachment":[{"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/media?parent=384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/categories?post=384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmarte.com\/en\/wp-json\/wp\/v2\/tags?post=384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}